{"id":465,"date":"2022-12-08T11:06:53","date_gmt":"2022-12-08T11:06:53","guid":{"rendered":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/?page_id=465"},"modified":"2022-12-08T13:21:36","modified_gmt":"2022-12-08T13:21:36","slug":"case-study-1","status":"publish","type":"page","link":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/case-study-1\/","title":{"rendered":"Case Study 1"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"465\" class=\"elementor elementor-465\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-700d4a3 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"700d4a3\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f67d61b\" data-id=\"f67d61b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bbf4207 elementor-widget elementor-widget-heading\" data-id=\"bbf4207\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Case Study 1<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9abd94f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9abd94f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bfd9f4d\" data-id=\"bfd9f4d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e0a948d elementor-widget elementor-widget-text-editor\" data-id=\"e0a948d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>To synthesize 1-Deoxy-D-Xylulose-5-phosphate and scale-up of the same to 5g scale. The five carbon sugar is a substrate for an enzyme called\u00a0 1-Deoxy-D-Xylulose-5-phosphate reductoisomerase (DXR). This enzyme is present in bacteria, protozoa and some alges. The advantage of this target is that there is no orthologous gene in host human. This is supposed to reduce the selectivity optimization burden. The substrate was required for screening four hundred and ten thousand compound library in a high throughput manner, justifying the requirement of five grams. This substrate could have been bought commercially but cost was the prohibiting factor, It is sold in the range of six hundred to eleven hundred US$\u00a0 for ten milligrams. Best negotiations brought it down only at two hundred and fifty thousand US$ for five grams in three months.<\/p><p>This substance was delivered in sixty days with two full time equivalents in required quantity, purity and biological activity in fifteen lakh INR. The scheme used was as follows.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2adf85b elementor-widget elementor-widget-image\" data-id=\"2adf85b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"638\" height=\"482\" src=\"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-content\/uploads\/2022\/12\/link.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-content\/uploads\/2022\/12\/link.jpg 638w, https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-content\/uploads\/2022\/12\/link-300x227.jpg 300w\" sizes=\"auto, (max-width: 638px) 100vw, 638px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Case Study 1 To synthesize 1-Deoxy-D-Xylulose-5-phosphate and scale-up of the same to 5g scale. The five carbon sugar is a substrate for an enzyme called\u00a0 1-Deoxy-D-Xylulose-5-phosphate reductoisomerase (DXR). This enzyme is present in bacteria, protozoa and some alges. The advantage of this target is that there is no orthologous gene in host human. This is &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/case-study-1\/\"> <span class=\"screen-reader-text\">Case Study 1<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_mi_skip_tracking":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"class_list":["post-465","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/pages\/465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/comments?post=465"}],"version-history":[{"count":16,"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/pages\/465\/revisions"}],"predecessor-version":[{"id":533,"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/pages\/465\/revisions\/533"}],"wp:attachment":[{"href":"https:\/\/testing.kalpakprojects.com\/Websites\/ANANT_PHARMASOL\/wp-json\/wp\/v2\/media?parent=465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}